Ledger containing lists and charts of smallpox inoculation cases and patient case histories of Boston physician John Jeffries (1745-1819), recorded from November 1775 to June 1802. Descriptions include patients' names, ages, and physical condition, method of inoculation and symptoms. The entries dated 1800-1802 are not in chronological order.

John Jeffries (1745-1819), A.B., 1763, Harvard College, Cambridge, Massachusetts, M.D., University of Aberdeen, Scotland, was a Boston physician and scientist. He was an assistant surgeon on a British naval vessel when the Revolutionary War commenced in 1775. A Loyalist, Jeffries evacuated Boston with British forces in 1776, and worked as a surgeon in a British military hospital in Halifax, Nova Scotia, until 1779, when he moved to London. In 1785, Jeffries became the first man (with Jean-Pierre Blanchard) to fly a balloon across the English Channel between England and France. He returned to Boston in 1790, and practiced medicine there until his death.