The Reed & Gardner records, dated 1777-1792, consist of bills, invoices, receipts, and correspondence related to operation of their general store, and papers signed by Isaac Reed and William Gardner dissolving their partnership. There are also papers generated during Isaac Reed's service as a justice of the peace in Littleton, and records related to his estate after his death in 1789. Included are bills and invoices for commodities received and sold at the general store, such as West Indies rum, dry goods, brandy, wheat, flour, spices, wood, and German steel, as well as bills for carpentry and other labor at the store, and a small amount of correspondence with customers and agents. Isaac Reed's justice of the peace papers consist chiefly of writs of attachment and summonses to appear before him in lawsuits related to debt. There are also personal papers of Isaac Reed, including some legal documents like land deeds, receipts, and correspondence, in addition to receipts and bills settled by his estate after his death in 1789.

Reed & Gardner was a merchant partnership in Littleton, Massachusetts, formed by Isaac Reed (1754-1789) and William Gardner. They ran a general store that sold rum, corn, flour, spices, wheat, and German steel, among other commodities. The partnership dissolved in 1784, and Isaac Reed maintained the business until his death in 1789. His wife, Mary, remarried to William Tuttle, who assumed oversight of the store in the 1790s and early 1800s. In addition to his business endeavors, Isaac Reed served as a justice of the peace in Littleton.