The William Tuttle records consist of bills, invoices, and receipts, dated 1790 to 1804, related to operation of a general store in Littleton, Massachusetts. The bulk of the the records are accounts and receipts to Tuttle from other merchants, among them David Carriel and Larkin & Hurd of Charlestown, Benjamin Hall, Jr., of Medford, and Joseph Peirce and Samuel Eliot of Boston, for commodities he carried in his store including dry goods, sugar, powder and shot, Souchong and Bohea tea, molasses, gin, rice, flour, and rum. There are additionally promissory notes, some personal bills and receipts, and a letter from Isaac Sparhawk Gardner, brother of William Gardner, one of the store's original owners, regarding a deed to be granted to the Tuttle family.

William Tuttle was a merchant in Littleton, Massachusetts, active from the 1790s to the early 1800s. He married Mary Reed, the widow of general store owner Isaac Reed (1754-1789) and took over Reed's business in 1790. The general store was originally operated by Isaac Reed and William Gardner, but the men dissolved their partnership in 1784, and Reed continued as sole proprietor until his death.